Two juniors make Harker history

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Two juniors became the first Upper School students to win a scholarship at the national finals of the Siemens Competition in Math, Science & Technology.

In Nov. 2013, Andrew Jin and Steven Wang were named finalists and earned top team honors for their research about anti-cancer drugs at the Region One Finals hosted by the California Institution of Technology. The team was then invited to present their project at the National Finals in Washington, D.C. one month later and placed third.

Their project, “Rational Discovery and Optimization of Synergistic Chemotherapy and Combinations: A Novel Framework Integrating Gene Perturbation Analysis and Machine Learning Algorithms,” explained their research about chemotherapy drug combinations by incorporating components such as computer modeling and biological experiments. The combinations they found are deemed “synergistic” in that their combined effect is greater than the sum of the individual effects.

During the last three months of research, science teachers Anita Chetty, Chris Spenner, Gary Blickenstaff, Mala Raghavan, and Michael Pistacchi guided the two students and gave them feedback on their project.

“Before the competition, we made a ton of changes based on [their] feedback, and we were able to improve the presentation significantly,” Andrew said. “We couldn’t have made it this far without all [their] help.”

In December, Andrew and Steven flew to Washington, D.C. to present their work to the public. Additionally, they participated in media training and an outreach program for which they went to an elementary school to demonstrate fun science experiments. During their down time, the two played “Just Dance 4” with other students whom they met on the trip.

“I learned a lot about perspective because everyone at the competition all shared something in common: a passion for research and science,” Steven said. “It was pretty inspiring to be with such a group of talented people and learn about their projects, whether they were about biology, computer science, or even nanotechnology.”

Andrew and Steven’s success mirrored their finding of combined drugs in that in both cases, they worked better as teams and achieved favorable results.